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ey0018.3-2 | Thyroid hormone action | ESPEYB18

3.2. A coregulator shift, rather than the canonical switch, underlies thyroid hormone action in the liver

Y Shabtai , NK Nagaraj , K Batmanov , YW Cho , Y Guan , C Jiang , J Remsberg , D Forrest , MA Lazar

Genes Dev. 2021;35(56):367378. doi: 10.1101/gad.345686.120.The longstanding concept of thyroid hormone (TH) action is summarized as the canonical switch model. This study adds important aspects of TH action to our current understanding, modifying this longstanding switch model to a shift model.According to the current concept, TH dependent gene...

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ey0016.11-4 | New Insights into Body Weight Regulation | ESPEYB16

11.4. Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity

OS Dallner , JM Marinis , YH Lu , K Birsoy , E Werner , G Fayzikhodjaeva , BD Dill , H Molina , A Moscati , Z Kutalik , P Marques-Vidal , TO Kilpelainen , N Grarup , A Linneberg , Y Zhang , R Vaughan , RJF Loos , MA Lazar , JM Friedman

To read the full abstract: Nature Medicine 2019; 25(3):507-516.This paper shows that quantitative leptin expression is controlled by redundant cis elements and trans factors that interact with the proximal promoter together with a long noncoding RNA.Friedmans research group discovered the adipocyte hormone leptin more than 20 years ago. They identified loss o...

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ESPE Yearbook of Paediatric Endocrinology

3.2. A coregulator shift, rather than the canonical switch, underlies thyroid hormone action in the liver

11.4. Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity

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